CJC-1295 (no DAC) + Ipamorelin (Blend)
What is CJC-1295 (no DAC) + Ipamorelin (Blend)?
CJC-1295 without Drug Affinity Complex (no DAC) is a synthetic analog of growth hormone–releasing hormone (GHRH) that stimulates the pituitary gland to naturally release growth hormone (GH) in short, physiologic pulses. Unlike the DAC version, the no DAC form has a much shorter half-life, allowing GH release patterns to more closely mimic the body’s natural rhythm. Ipamorelin is a selective growth hormone secretagogue (GHS) and ghrelin receptor agonist that increases GH secretion without significantly affecting cortisol or prolactin. When studied together, these peptides may have complementary effects on GH output and recovery.
Mechanisms of Action
CJC-1295 (no DAC) + Ipamorelin may work together by:
- CJC-1295 (no DAC): Binding to GHRH receptors to boost GH pulse amplitude and frequency in a short-acting, natural pattern
- Ipamorelin: Activating ghrelin receptors (GHS-R1a) to enhance GH pulses without unwanted hormone spikes
- Increasing circulating IGF-1 to support protein synthesis, tissue repair, and metabolic regulation
- Supporting lean muscle preservation, connective tissue health, and fat metabolism in research models
- Enhancing overall GH output by combining two distinct hormone stimulation pathways
CJC-1295 (No DAC)
CJC-1295 (without DAC) is a synthetic peptide designed to mimic Growth Hormone-Releasing Hormone (GHRH), stimulating the pituitary gland to naturally produce and release growth hormone (GH). Unlike the DAC version, CJC-1295 (No DAC) has a shorter half-life, making it better suited for more controlled and pulsatile GH release—closer to the body's natural rhythm.
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Ipamorelin
Ipamorelin is a selective growth hormone secretagogue (GHS) peptide that stimulates the body's natural production of growth hormone (GH). It works by mimicking ghrelin, the "hunger hormone," but without significantly increasing cortisol or other unwanted side effects seen with older GH peptides. It's commonly studied for its potential benefits in muscle growth, recovery, and anti-aging.
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Research Highlights
CJC-1295 (No DAC)
Mimics Natural, Pulsatile GH Secretion
CJC‑1295 without DAC is a short-acting analog of GHRH that reproduces the body’s natural growth hormone (GH) pulse patterns, with a half-life of around 30 minutes.
Precise Control Without Receptor Desensitization
Its short duration allows for frequent administration that avoids pituitary down-regulation—a key advantage for maintaining physiologic GH sensitivity.
Rapid GH Response & IGF‑1 Pathway Activation
Used in conjunction with GHRP peptides like Ipamorelin, CJC‑1295 (no DAC) can enhance GH pulse amplitude and stimulate downstream IGF‑1 signaling for anabolic effects.
Clinical Potential in Muscle Growth, Fat Metabolism & Aging
Clinical and preclinical studies have linked CJC‑1295 (general notes across versions) to increases in GH/IGF‑1, improvements in body composition, sleep, and anti-aging markers—though human data remains limited for No DAC specifically.
Ipamorelin
Selective GH Secretagogue (GHS‑R1a Agonist)
Ipamorelin binds specifically to the ghrelin receptors in the pituitary, inducing growth hormone (GH) release without significantly impacting cortisol, ACTH, or prolactin—offering a cleaner profile compared to other GHRPs.
Musculoskeletal Support & Bone Health
Animal studies indicate that Ipamorelin may counteract glucocorticoid-induced muscle catabolism and increase bone mineral content, particularly enhancing tibial growth and bone density in female rats.
Precise, Pulsatile GH Release
Ipamorelin closely mimics natural GH secretion patterns by delivering targeted pulses, which helps maintain physiological hormone balance and potentially improves metabolic responses.
Potential Anti-Aging & Recovery Applications
Due to its selectivity and minimal hormonal side effects, Ipamorelin is under investigation as a research tool for muscle recovery, anti-aging protocols, and metabolic studies.
Molecular Structure
CJC-1295 (No DAC)
Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser
C₁₅₂H₂₅₂N₄₄O₄₂
3367.88 g/mol
Ipamorelin
Aib-His-D-2-Nal-D-Phe-Lys-NH₂ (Aib = 2-aminoisobutyric acid, 2-Nal = 2-naphthylalanine)
C₃₈H₄₉N₉O₅
711.86 g/mol